Africa Flow Chemistry Overview

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Africa Microreactor Chip

Africa Microfluidics System

Africa Flow Chemistry Systems

Africa Flow Chemistry Overview

Africa is a fully automated, flexible and easy-to-use microreactor flow system. The Africa system allows R&D chemists working in discovery and process development to accelerate compound synthesis and reaction optimization.


[spoiler title=”Africa benefits:” style=”fancy” icon=”chevron-circle”]

  • Walk away synthesis: Fully automated hardware is controlled by the Africa software to enable unattended runs. Reagents are injected and products are collected automatically.
  • Faster reactions: Increase reaction rates over 100 fold by superheating reactions significantly above reflux e.g. dichloromethane to 100°C, acetonitrile to 150°C and water to 170°C.
  • Cleaner reactions: Reduced impurities via excellent, reproducible reaction control and optional use of solid phase reagents/catalysts/scavengers.
  • Inline aqueous work-up: The Flow Liquid Liquid Extraction Module (FLLEX) enables two immiscible phases to be mixed and separated in flow, immediately following the reaction.
  • Online analysis: A sample of reaction mixture can be taken, diluted and analyzed by HPLC in an entirely automated fashion.
  • Scale-up: Production rates up to kg overnight.
  • Automated LogP / LogD analysis: Excellent correlation with shake flask method.
  • Rapid development: Reaction time, temperature and equivalents can be rapidly varied using mg of substrate.
  • Reactions not possible with batch synthesis: Extremely quick reaction times, reagent additions, temperature changes and quenches are possible.
  • Automated blockage protection: Pressure sensors continually monitor every flow channel.
  • Wide temperature range: Heat reactions up to 250°C or cool down to 0°C.
  • Chemically resistant: Glass and PTFE/ fluoropolymer wetted part
[/spoiler] [spoiler title=”Africa Systems” style=”fancy” icon=”chevron-circle”]
Africa can be configured into a wide range of different flow chemistry systems. Click on the following systems to read more:
  • 2 Channel Synthesis
  • 4 Channel Synthesis
  • Synthesis and Collection
  • Synthesis and Automation
  • Synthesis and Analysis
  • Synthesis and FLLEX
  • Synthesis, FLLEX and Product collection
  • Synthesis, Analysis and Liquid Handling
  • Fully Automated Africa Flow Chemistry System
  • LogP/LogD Determination